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Mark Yarmarkovich, PhD

Principal Investigator

Assistant Professor

NYU School of Medicine

Dr. Mark Yarmarkovich is focused on developing safe and effective cancer immunotherapies through innovations in biotechnology. He has worked in industry at Genentech and completed his PhD at the University of Pennsylvania and postdoctoral work with John Maris at the Children's Hospital of Philadelphia. He has worked across disciplines including: oncology, protein chemistry, immunology, and computational biology. He has applied these multidisciplinary experiences to addressing the major challenges in developing the next generation of immunotherapies.

 

He has led the development of new technologies for the discovery of tumor-specific targets and the engineering of target-specific receptors. He has discovered novel immunotherapy targets derived from previously undruggable oncoproteins and engineered CAR T cells capable of specifically killing tumor cells.

 

Dr. Yarmarkovich led the discovery of cross-HLA recognition of Peptide-Centric (PC)-CAR T cells, allowing for significantly expanded application of immunotherapies. Collectively, the application of his efforts has resulted in a PC-CAR T cells entering first-in-class clinical trial in pediatric neuroblastoma in 2024 and a pipeline of PC-CARs being additional cancers. His work has led to the formation of two companies. His lab is focused on developing the next generation of immunotherapies with the goal of being able to help any cancer patient. 

Team Members

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Maxence Dellacherie, PhD

Senior Scientist

Maxence completed his BSc and MSc. in Bioengineering at EPFL, Switzerland where he initially trained with Prof. Jeffrey Hubbell’s, developing fusion proteins with enhanced ECM affinity for controlled growth factor delivery. He then joined Prof. David Mooney’s group at Harvard University, where he completed his PhD in Bioengineering. His thesis work focused on the development and application of spontaneously assembling Mesoporous Silica Rods (MSR) scaffolds as a cancer vaccine platform. Using the ability of the MSR’s 3D micro-environment to recruit dendritic cells and locally deliver them with immunostimulatory molecules, he studied and optimized the system for the generation of robust and long-lasting T and B-cell responses against small peptides and protein domains. In collaboration with Prof. Kai Wucherpfennig at the Dana Farber Cancer Institute, they investigated the effect of MSR immunization against MICA/B, a stress-inducible membrane-bound NKG2D ligand that is abnormally shed from cancer cells as an immune escape mechanism. Vaccine-induced anti-MICA/B antibodies stabilized the ligand at the cell surface and rescued NK and T-cell mediated cytotoxicity in vivo. Compared to monoclonal antibody therapy, the vaccine approach could engage multiple arms of the immune system, drastically altering the tumor microenvironment and improving therapeutic benefits in various solid tumor models. After graduating, he became the Immunology Team Lead at a Boston-based biotech startup where he worked 2 years on the development of iPSC-derived cell therapies. In 2023, Maxence joined the Yarmarkovich lab as a Senior Scientist where he’s using his experience to contribute to the lab’s mission of translating research into safer and more efficacious cancer immunotherapies.

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Guangyuan (Frank) Li, PhD

Postdoctoral Fellow

Guangyuan is a computational biologist specializing in algorithm and pipeline development within the field of cancer immunotherapy. He's completed his PhD in the Biomedical Informatics Program at Cincinnati Children’s Hospital Medical Center (CCHMC) between 2019 and 2023. Guangyuan's career goal is to combine his computational training with his enthusiasm for cancer biology. Outside of work, you can find him indulging in rock climbing, basketball, and all things outdoorsy.

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Minkyung Kim

Lab Manager

Minkyung graduated from University of Florida in 2018 majoring in Biology with a concentration in veterinary medicine. She's worked as a veterinary and nurse technician where she grew her passion for working in medicine. After working in inpatient rehabilitation working with variety of patients with different comorbidities such as oncological, neurologic, cardiac, and musculoskeletal injuries and through working closely with pediatric oncology patients, she wishes to pursue a doctorate degree in pediatric oncology. With the Yarmarkovich Lab, she wishes to learn and pursue her interest in cancer immunotherapy. In her spare time, Minkyung likes to cuddle with her cats Dwight and Mo with a nice book, or go to the gym to lift weights with her friends.

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Xinya Liu

Research Associate

Xinya is from Wuhan, China. He majored in biotechnology at Guangdong Technion before attending the biotechnology M.S. program at NYU Tandon School of Engineering. His previous research was about nanoplasmonic immunoassay microarray chips, where he accumulated relevant knowledge of cancer treatment and CAR T therapy. He's interested in CAR T therapy, and his current project is developing a logic-gated CAR/BiTE platform. Outside of work, his interests are working out and video games.

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Rachel Yamin, PhD

Senior Scientist

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Darren Taylor, PhD

Postdoctoral Fellow

Profile bio in progress

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Hong Duck Kim, PhD

Scientist

Dr. Kim is widely experienced in government, biotechnology, and academia. He’s received his Ph.D. in Cancer Biology, Immunology, Pharmacology, and Chemotherapy at the Laboratory of Biomedical Research in the Department of Pharmaceutical Science, University of Tokyo, Japan in 1991 through 1996. His post-doctoral fellowship investigated PSD95 and its interaction with NMDA receptor subtype during synaptogenesis from the National Institute of Bioscience and Human Technology, Department of Biomolecular Engineering (today known as Advanced Industrial Science and Technology (AIST)) in Tsukuba, Japan. You can find his published studies from 1999 in Nature Neuroscience. Dr. Kim has also worked at the University of Rochester (UR), UAB in Alabama, and UIC at IL, in the USA in 2000 through 2008, where he’s joined an NIH-funded study that focused in the development of a detection and evaluation system of pneumococcal polysaccharide vaccine- a CRM conjugate vaccine for geriatric patients in clinical immunology. In addition, he’s participated in an NIH-funded project, “Alzheimer vaccines, Non-invasive vaccination by DNA-based vectors,” which focused on cellular aging in Alzheimer's disease and CNS vaccine development. A couple of his other experiences include biotech research in gene therapy, adjuvant development in sendal virus and new drug discovery using fermentation with pharmaceutical companies in Korea, and cell therapy by utilizing a multi-discipline strategy by exploring neoantigen and a delivery system to improve the Quality of Life in patients. Dr. Kim is happy to carry his robust background in research and R& D work, biomedical science, and translational research to working with the Yarmarkovich Lab in CAR-T cell development.

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Aman Sharma

Research Associate

Aman is from India. He has the academic background in Bioprocess Engineering and Biotechnology. He earned his Master’s degree from IIT Madras, and his Bachelor’s degree in Biotechnology from VIT Vellore. For his Master's thesis, Aman delved into a research project titled "Production of Omega-3 & 6 Fatty Acids from Supplement of Lactic Fermented Culture & Stoichiometric-Modelling-Based Analysis of Docosahexaenoic Acid (DHA) Production", conducted in collaboration with Polytech Clermont-Ferrand, Auvergne, France. Currently, Aman's research interests lie at the intersection of cancer biology, bioinformatics, and immunology. In his leisure time, Aman enjoys immersing himself in the world of entertainment, often found binging Netflix. Additionally, he has a keen interest in culinary exploration.

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Michele Palamenghi, PhD

Postdoctoral Fellow

Michele Palamenghi graduated in 2017 in “Pharmaceutical Biotechnology” at the University of Pavia, Italy. Here, Michele started to grow interest in the combined use of cell and gene therapy to treat different types of diseases. This led him to enroll to the “Regenerative and Molecular Medicine” PhD program at the University of Modena and Reggio Emilia, Italy, under the supervision of Professor De Luca, where in 2021 he graduated. During his PhD, Michele participated to the development of novel safety assays and gene therapy approaches to tackle rare genetic epithelial disorders, such as epidermolysis bullosa and ectrodactyly-ectodermal dysplasia clefting syndrome (EEC). In this time, he was able to use his passion for art to draw several of the scientific article illustrations that were published by De Luca’s lab.

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Jason Tang, PhD

Postdoctoral Fellow

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Omar Uriel Guzman-Bringas

Research Associate

Uriel double majored in Pharmaceutical-Biological Chemistry and Pharmaceutical Chemistry and Biology at the Universidad Nacional Autónoma de México in 2017. His degree at the UDIBI lab from Instituto Politécnico Nacional focused on obtaining human CDRH3 from healthy donors, to generate a semi-synthetic library called “ALTHEA Gold Libraries”. As an analyst chemist he's worked in the development and validation of new libraries based on the "ALTHEA Gold Libraries", discovery of novel therapeutic antibodies against different target (TNF alfa, Chikungunya Virus, CD20, CD36, hPD1), and in the development of therapeutic antibodies against COVID-19 in Mexico. Afterwards, as the "Head of Discovery of Therapeutic Antibodies Area", he worked internationally in finding antibodies against interest protein. Currently, his research interest is in developing novel techniques in panning and screening to find antibodies with high therapeutic potential. Personal interests: find/visit new places to enjoy the connection with the nature. Meet new people to share experiences and stories. Learn to cook new dishes, as well as going out dancing with friends.

Ben Monroe

Ben Monroe

Research Associate

Ben graduated cum laude from Northwestern University in the spring of 2023 with a B.S. in biomedical engineering and a minor in chemistry. While at Northwestern, Ben conducted research with the Mrksich group and advanced development of a prostate cancer theranostic. His research culminated in an undergraduate honors thesis entitled, "Targeting Small Molecule Inhibitors: Optimization of Synthesis Routes and Characterization via MALDI-TOF MS and NMR Spectroscopic Analysis." Ben has completed multiple internships including one at YCHAROS, an open-science company dedicated to characterizing commercially available antibodies. Additionally, he interned at Regeneron Pharmaceuticals where he aided scientists developing cancer vaccines and accumulated salient knowledge of cancer treatments and immunotherapies. This experience encouraged him to pursue cancer research as a career. Currently, Ben's primary research interests are cancer biology, immunology, and cancer therapeutic development. Outside of the lab, his interests are playing the drums, pick-up basketball, and travel.

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Zachary Harpaz

Student Research Intern

Zachary is currently attending Pine Crest High School in Florida. He is passionate about applying computer science and machine learning to biology. Currently, he is working on a novel target discovery software for CAR T cells. Zachary's last project was also a target discovery project, where he utilized AI to identify new targets for Glioblastoma Multiforme. He works for the Yarmarkovich lab virtually over the school year and has a summer internship in the lab to learn from our scientists.

Eliana Shapiro

Eliana Shapiro

Assistant Research Technician

Eliana graduated cum laude from Duke University in the Spring of 2023 with a B.A. in neuroscience and a certificate in innovation and entrepreneurship. While at Duke, she was a member of an interdisciplinary team where she worked to develop a decoded neurofeedback protocol in the context of racial bias mitigation. She has previously served on the Children’s Hospital of Philadelphia Youth Advisory Council and completed a fellowship in biomedical research at The Wistar Institute. Additionally, Eliana has completed internships in strategy consulting and private equity. She is an incoming analyst at ClearView Healthcare Partners, a strategy consulting firm for the life sciences industry. Outside of the lab, Eliana is exploring her interest in cooking as a student at the Institute of Culinary Education. She also enjoys watching Duke basketball games and traveling.

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David Beeman Martignetti

Rotating PhD Student

David B. Martignetti graduated in 2021 with a Biochemistry BS from Boston College. While at Boston College he worked with axonal guidance and frataxin at the Lowery Lab. This experience informed his decision to follow a career in research. After graduation David did two years at The D’Andrea Lab at Dana Farber Cancer Institute. While at DFCI he worked with small molecule inhibitors targeting defects in DNA damage repair pathways as part of the Center for DNA Damage Repair, with the aim to characterize and discover synthetic lethal treatments for common mutations in breast and ovarian cancers. David is now a rotating PhD student in the Yarmarkovich lab who is focused on developing technology and translational cancer discoveries during his PhD. Outside of the lab David enjoys XC-Skiing, Guitar, Sailing and Hiking.

Alumni

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Gabriella Torres

Undergraduate Student

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Pamirhan Kaya

Student Research Intern

Xiaoxuan Zhong

Xiaoxuan Zhong

Rotating PhD Student

Teams and Funding

The Yarmarkovich lab is part of several international teams focused on developing the next generation of cancer immunotherapies.

Lab Life

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